Fig. 4: Application of SigXTalk to the HNSCC dataset.
From: Dissecting crosstalk induced by cell-cell communication using single-cell transcriptomic data
a The CCC patterns among cell clusters. The width of links represents the communication strength. b.The circle plot of the top-30 activated ligand-receptor pairs with the highest interaction strength with malignant as the receivers. The width of links represents the interaction strength. c The distribution of the number of crosstalk pathways for each target gene in malignant. Inner panel: the number of crosstalk pathways of 6 HNSCC markers. d The signal-target regulatory pattern of the top-15 targets that have the most crosstalk pathways in malignant. Upper: the contribution of the signals to the expression of these targets; Lower: the heatmap of the total regulatory strength (TRS) values for each signal-target pair. e The alluvial diagram of the top-20 pathways targeting the 6 HNSCC markers with the highest PRS values. The width of flow represents the PRS value. f The ridge diagram for the fidelity distribution of each SSC given the target KRT5. g The heatmap of the fidelity of each pathway that regulates the target KRT17. The boxplots illustrate the distribution of fidelity (Fid) values for each signal or SSC (sample size: 27 SSCs for each signal and 22 signals for each SSC). h The distribution of each target’s specificity regulated by 4 common signals in 4 cell clusters. Inner panel: the top-5 targets regulated by 4 signals in the malignant cell cluster with highest specificity. Boxplot elements: center line, median; box limits, upper and lower quartiles; whiskers, 1.5x interquartile range; points, outliers. Source data are provided as a Source Data file.
