Fig. 4: Allele-specific chromatin conformation shows in PWS imprinting domains by Hi-C analysis.
From: Mechanism of EHMT2-mediated genomic imprinting associated with Prader-Willi syndrome
a This Juicebox screenshot visualizing a region of 1.7 Mb locus (chr15:24,500,000-26,200,000, hg38) at 5-Kb resolution. (Normalization; SCALE). b Wash U Epigenome Browser snapshot showing CTCF (control) Hi-C track of a 5.5 Mb region of human chromosome 15q11.2-q13 at 500 bp resolution normalized using SCALE. The triangle shapes in the Hi-C track depict chromatin domains in human fibroblasts derived from PWS and AS patients (The color scale of the heatmap; higher contact counts corresponding to a darker color). c Genome viewer screenshot illustrating 1D representation of the DNA fragment that forms the loop in PWS-associated imprinted domains of maternal or paternal chromosome, partially matched with ATAC-seq peaks. (UBE3A; a paternal and neuron cell type specific imprinted gene in brain).
