Fig. 2: SAR and crystal structures of selected double-ortho substituted analogs.
From: Scaffold-hopping for molecular glues targeting the 14-3-3/ERα complex
a MS bar graphs at 1 μΜ. For each compound, time course experiments were performed with measurements at 1 h, 8 h, 16 h, and 24 h. ERα data are shown with different colors for each compound, and apo data in grey. b–e Crystal structures of 14-3-3σ/ERα with compounds 17 (dark pink sticks) (PDB 9I70), 19 (teal sticks) (PDB 9I71) and overlays of crystal structures for compounds 17 (dark pink sticks) (PDB 9I70), 20 (pale green sticks) (PDB 9I73), 21 (pale purple sticks) (PDB 9I74) and 25 (bright yellow sticks) (PDB 9I75).
