Fig. 2: VLRA, VLRC and VLRF locus organization in sea lamprey. | Nature Communications

Fig. 2: VLRA, VLRC and VLRF locus organization in sea lamprey.

From: Variable lymphocyte receptor F is generated via somatic diversification and expressed by lamprey T-like cells

Fig. 2

a Germline VLRA and VLRF genes are located on chromosome 58, with donor cassettes distributed in two genomic clusters (Cluster I and Cluster II) on chromosome 58. b Genomic organization of the sea lamprey VLRA and VLRF loci on chromosome 58. Cluster I and Cluster II on chromosome 58 contain 129 and 144 donor cassettes, respectively. c Germline VLRC and adjacent donor cassettes are located on chromosome 7. Chromosome 7 is much larger than chromosome 58, as indicated by the gap. d Germline VLRC and the donor cassette cluster on chromosome 7. This cluster contains 18 donor cassettes primarily used for VLRC assembly. For figures (b and d), the cassettes are presented according to their genomic spacing, although the icons are not to scale. Filled triangles above each donor cassette and the germline VLR gene indicate the transcriptional orientation.

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