Fig. 6: The effects of silencing GC synapses and PC synapses on in vivo firing properties. | Nature Communications

Fig. 6: The effects of silencing GC synapses and PC synapses on in vivo firing properties.

From: Processing reliant on granule cells is essential for motor learning but dispensable for social preference and numerous other cerebellar-dependent behaviors

Fig. 6

a–d PC firing in Crus I in vivo was examined in adult mice for GC (α6) TKO and control mice. a Simple spikes (downward spikes) and complex spikes (upward spikes marked as red asterisks) are apparent in a PC recording from a control mouse. b As in (a), but for GC (α6) TKO mouse. c Firing rates and variability (CV2) of control (black) and GC (α6) TKO (orange) mice are summarized for simple spikes. The definitions of box plot boundaries and components are detailed in the ‘Statistical Analysis’ section of the Methods. d PC complex spike firing rates, variability (CV2) and duration of the pause following the complex spike are shown for control (black) and GC (α6) TKO (orange) mice. e, f Firing rates (e) and CV2 (f) of the lateral CbN neurons are summarized for control mice (black), GC (α6) TKO mice (orange) and PC (PCP2) TKO mice (blue). For statistics: c, d GC (α6) TKO and control: n = 9 cells (2 mice) and 7 cells (2 mice). e, f GC (α6) TKO and control: n = 68 cells (2 mice) and 47 cells (2 mice), PC (PCP2) TKO and control: n = 60 cells (2 mice) and 82 cells (2 mice). A two-tailed t-test (d GC (α6) group; e PC (PCP2) group) or a two-tailed Mann-Whitney test (d GC (GABRA6) and PC (PCP2) group; e GC (α6) and PC (PCP2) group) was used. *p  <  0.05, **p  <  0.01, ***p  <  0.005. Detailed statistical results are presented in Supplementary Table 1.

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