Fig. 1: Schematic illustration of the study design.
From: Mechanically robust neuroprotective stent by sequential Mg ions release for ischemic stroke therapy
Preparation: PLCL is synthesized via copolymerization of L-lactide and ε-caprolactone. Magnesium sulfate (MgSO4) powder is mixed into the molten PLCL to form PLCL/MgSO₄ composites with varying MgSO4 concentrations. The composite is extruded as a hot-melt filament through a 3D printer nozzle, adhering to either a rotating rod or previously deposited filaments, ultimately fabricating stents. Implantation: A middle cerebral artery occlusion (MCAO) rat model is established. The fabricated stents are implanted into the common carotid artery (CCA). Neuroprotection: Mg2+ ions (blue spheres) released from the stent migrate with blood flow into the infarcted region (gray area). There, they antagonize Ca2+ overload and scavenge reactive oxygen species (ROS) in damaged neurons, exerting a neuroprotective effect.
