Fig. 7: In vivo neuroprotection analysis of PLCLxMS in tMCAO rat models on the 7 days after ischemia/reperfusion injury.
From: Mechanically robust neuroprotective stent by sequential Mg ions release for ischemic stroke therapy
A Schematic diagram of stent strut implantation process. B Brain slices stained with TTC to differentiate between healthy tissue (red) and damaged tissue (white). C Quantification of brain infarct volume from (B). D, E Brain slices with Nissl staining and quantification of Nissl bodies; scale bars: 1 mm and 25 µm. F Evaluation of brain water content ratio. G Representative Evans blue extravasation image illustrating blood-brain barrier disruption. H Quantification of cerebral Evans blue content. I Measurements of CBF before, during, and after surgery. J Comparison of relative CBF across groups. Source data and exact P values are provided as a Source data file. Two-way analysis of variance (ANOVA) with a Tukey/Games-Howell post hoc test for multiple comparisons. Sample size: n = 6 biologically independent replicates. *P < 0.05, **P < 0.01, ***P < 0.001, tMCAO+PLCL5MS or tMCAO+PLCL10MS vs. tMCAO group; # P < 0.05, ## P < 0.01, ### P < 0.001, c or tMCAO+PLCL10MS vs. tMCAO+PLCL group; §P < 0.05, §§ P < 0.01, §§§ P < 0.001, tMCAO+PLCL10MS vs. tMCAO+PLCL5MS. Data are presented as mean values ± SD.
