Fig. 1: The process to re-establish homeostasis in aging-induced bone marrow collapse via the rejuvenation of senescent LepR+ cells with the NO nanopump.
From: Regenerating aged bone marrow via a nitric oxide nanopump
A Construction of NO nanopump targeting LepR+ cells. B The NO nanopump scavenges the accumulated H2O2 in the aged BM, followed by the production of 1,2-dioxetanedione (DOD), the high-energy intermediate to directly excite the NO donor, causing in situ NO release to rejuvenate the senescent LepR+ cells by activating glycolysis signaling. C Rejuvenation of senescent LepR+ cells with the NO nanopump reestablished homeostasis via regeneration of HSCs, blood vessels, lymphatic vessels, and nerve fibers in aged BM.
