Fig. 4: Lineage-specific community interactions in the gut for the rm cohort. | Nature Communications

Fig. 4: Lineage-specific community interactions in the gut for the rm cohort.

From: Quantifying the intra- and inter-species community interactions in microbiomes by dynamic covariance mapping

Fig. 4

a Co-clustering E. coli cluster clones with the different bacterial families suggest clone-specific community interactions. The clonal lineage-to-species interactions are broadly reproducible across different mice, whereby the dynamics of C1 is related to Lachnospiraceae in rm1-4, and C8 of rm1-2 and C10 of rm3-4 are related to Lactobacillaceae. b E. coli clone and bacterial community interactions are strongest when coming from the same cohort. Co-clustering is measured by a mixing coefficient that compares the distances in the hierarchical tree among families with distances between families and clonal clusters (Methods, Supplementary Information section C). Statistical significance was assessed using a two-sided Wilcoxon rank-sum test (n = 1276). Significance is indicated as follows: p ≤ 0.05 (*), p ≤ 0.001 (***).

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