Fig. 5: The similarity of clonal lineage dynamics across mice is partly driven by identical barcodes. | Nature Communications

Fig. 5: The similarity of clonal lineage dynamics across mice is partly driven by identical barcodes.

From: Quantifying the intra- and inter-species community interactions in microbiomes by dynamic covariance mapping

Fig. 5

a Similarity between the time series of clonal clusters across all 4 gf mice quantified by Pearson correlation. Matrix elements are clustered based on hierarchy (dendrograms indicated). Colors indicate the clonal cluster’s identity, while the shape indicates the mouse of origin. b The similarity in barcode identity between the different clonal cluster is quantified by the overlap coefficient, OC(A, B) = |A∩B|/min(|A|, |B|), where A and B are the sets of unique raw DNA barcodes that belong to two dominant clonal clusters. Identities of matrix elements are similar to panel (a). c Scatter plot of the similarity in dynamics between two clonal clusters by Pearson correlation vs. similarity in their barcode identity by overlap coefficient. Overlap coefficients satisfying two-sided P value <0.05, calculated from z-scores derived via bootstrap resampling, are shown in blue; otherwise, they are shown in gray (Methods). The size of the circle is proportional to the significance of the overlap coefficient. d–f Similarity in dynamics and barcode identity for the colonization in mice with the resident microbiome.

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