Fig. 1: Engineering sono-activable and biocatalytic 3D-printed scaffolds for limb salvage therapy of osteosarcoma. | Nature Communications

Fig. 1: Engineering sono-activable and biocatalytic 3D-printed scaffolds for limb salvage therapy of osteosarcoma.

From: Sono-activable and biocatalytic 3D-printed scaffolds for intelligently sequential therapies in osteosarcoma eradication and defect regeneration

Fig. 1

a Synthesis of the ICTO and ICTO-modified 3D-printed HA scaffolds (HS-ICTO). b Sono-activable and versatile biocatalytic ROS generation in intelligent and controllable osteosarcoma eradication. TME indicates tumor microenvironment. c Excess endogenous H2O2 scavenging and redox homeostasis remodeling from the defect area for superior bone reconstruction. BMP-2 bone morphogenetic protein-2, Runx2 Runt-related transcription factor-2, COLI type I collagen, RANKL receptor activator of nuclear factor κB ligand, HIF-1α hypoxia-inducible factor 1-alpha, MMP matrix metalloproteinase, NFATc1 nuclear factor of activated T-cells, cytoplasmic 1, ACP5 acid phosphatase 5.

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