Fig. 3: The structure of human LIAS.
From: Structural basis for catalysis by human lipoyl synthase
A cartoon representation of a the overall structure of LIAS; b the active site cavity of LIAS formed between two [Fe4S4] clusters with dithiothreitol (DTT) (two conformations) bound to the RS iron-sulfur cluster ([Fe4S4]RS) cluster. The mesh is contoured at 2.5 σ. LIAS color code: N-terminal domain (tan); RS domain (white); C-terminal α-helix (purple); iron–sulfur atoms of the auxiliary ([Fe4S4]AUX) and [Fe4S4]RS clusters are represented as orange and yellow balls, respectively.
