Fig. 5: A cartoon representation of the structure of the LIAS in complex with 6-mercaptooctanoyllysyl H-protein (6S-OCT-Hpro). | Nature Communications

Fig. 5: A cartoon representation of the structure of the LIAS in complex with 6-mercaptooctanoyllysyl H-protein (6S-OCT-Hpro).

From: Structural basis for catalysis by human lipoyl synthase

Fig. 5

The overall structure of LIAS-6S-OCT-Hpro in the presence of SAM (a); the active site of the LIAS-6S-OCT-Hpro covalent complex in the presence of SAM (b) or in the presence of 5’-deoxyadenosine (5’-dAH)+Met (c). The mesh is contoured at 2.5 σ. LIAS color code: N-terminal domain (tan); RS domain (light gray); C-terminal α-helix (purple); iron–sulfur atoms of the auxiliary ([Fe4S4]AUX) and radical SAM ([Fe4S4]RS) clusters are represented as orange and yellow balls, respectively.

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