Fig. 10: Mineralocorticoid receptor (MR) activation promotes experimental intestinal fibrosis through neutrophil gelatinase-associated lipocalin (NGAL) pathway. | Nature Communications

Fig. 10: Mineralocorticoid receptor (MR) activation promotes experimental intestinal fibrosis through neutrophil gelatinase-associated lipocalin (NGAL) pathway.

From: Mineralocorticoid receptor activation contributes to intestinal fibrosis through neutrophil gelatinase-associated lipocalin in preclinical models

Fig. 10

Aldosterone (Aldo), MR ligand promotes fibroblast activation while MR antagonism by spironolactone inhibited it. NGAL is a downstream MR target in intestinal fibrosis. MR antagonism reduced extracellular matrix production in smooth muscle cells (SMC), intestinal fibroblasts, and intestinal endothelial cells. Created in BioRender67.

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