Fig. 1: Intracranial EEG and directed connectivity.
From: Intracranial directed connectivity links subregions of the prefrontal cortex to major depression
A All participants had intracranial electrodes bilaterally implanted in the prefrontal cortex (PFC). The prefrontal subregions of interest were the dorsolateral prefrontal cortex (dlPFC), the orbitofrontal cortex (OFC), and the anterior cingulate cortex (ACC). Red circles highlight the dlPFC (Area 10/46), OFC (Area 11), and ACC (Area 24/32) contact locations that were selected based on expert ratings of neuroanatomy. For each participant, two contacts per region (one per hemisphere) were selected to compare connectivity within the left vs right PFC. B Analysis pipeline shows progression from raw intracranial EEG data to directed connectivity using multivariate autoregressive (MVAR) models (see “Methods”). Brain image generator: multi-modal neuroimaging analysis and visualization tool151. OFC orbitofrontal cortex, dlPFC dorsolateral prefrontal cortex, ACC anterior cingulate cortex.
