Fig. 4: Directed connectivity magnitudes across PFC subregions in each hemisphere.
From: Intracranial directed connectivity links subregions of the prefrontal cortex to major depression
Across all participants (n = 6), paired two-sided t-tests were conducted between the left PFC and right PFC homologues to determine which hemisphere had stronger inter-regional communication. A All communication involving the ACC was higher in the left hemisphere, including directed connectivity from the ACC to the dlPFC (p < 0.001), dlPFC to ACC (p < 0.001), OFC to ACC (p = 0.014), and from the ACC to the OFC (p = 0.005). B In the right hemisphere, directed connectivity from the orbitofrontal cortex (OFC) to the dlPFC (p = 0.011), and from the dlPFC to the OFC was higher (p = 0.003). These differences in connectivity magnitudes suggest that communication between PFC subregions is specialized in each hemisphere. All t-test results were false-discovery rate (FDR) corrected for the multiple comparisons across hemispheres. X’s within each box show the mean directed connectivity, vertical lines indicate medians. Whiskers mark the minimum and maximum values within 1.5× the upper (Q1) and lower (Q3) interquartile range, and outliers are indicated by single data points beyond this range. *asterisks indicate significant differences between hemispheres (p < 0.05). OFC orbitofrontal cortex, dlPFC dorsolateral prefrontal cortex, ACC anterior cingulate cortex.
