Fig. 2: Associations between brain connectivity and covariance in SV2A-PET w scores.
Covariance matrices of SV2A-PET w scores in CU Aβ- subjects (a, n = 54) and Aβ+ participants (b, n = 91). Group-average Fisher-z-transformed functional connectivity (FC) matrix (c) and log-transformed structural connectivity (SC) matrix (d) from 58 CU subjects with no evidence of abnormal amyloid-PET or tau-PET binding. (e-h) Density plots illustrated the distribution of the SV2A w-score covariance and brain connectivity. Scatterplots show the relationship between group-average functional connectivity and the covariance of the SV2A-PET w score in the CU Aβ- (i) and Aβ+ participants (j), as well as the relationship between structural connectivity and SV2A-PET w score covariance in Aβ + (k). β values were estimated by linear regressions. All two-sided p values estimated from linear regression models are <2.2 × 10⁻³⁰⁸. Linear model fits are indicated with 95% confidence intervals. To validate this association against the network topology, a one-sided permutation was performed by comparing the exact regression-derived β value against the null distribution from 1000 rewired network matrices (all prewired < 0.001). l The associations between functional connectivity and SV2A w-score covariance in CU Aβ- and Aβ+ participants were compared by two-sample t-test from 1000 bootstrapped samples (two-sided p < 2.2 × 10⁻³⁰⁸). m The associations derived from functional connectivity and structural connectivity in Aβ+ subjects were compared by paired t-test from 1000 bootstrapped samples (two-sided p = 4.25 × 10⁻2³). Boxes represent the interquartile range, with the median indicated by the center line. The bounds of the box correspond to the 25th and 75th percentiles. Whiskers extend to the minimum and maximum values within 1.5 interquartile range. FC functional connectivity, SC structural connectivity. Source data are provided in a Source data file.
