Fig. 6: MT-associated Kif5bMoNeIAK undocks its neck linker in the presence of ADP. | Nature Communications

Fig. 6: MT-associated Kif5bMoNeIAK undocks its neck linker in the presence of ADP.

From: Microtubule association induces a Mg-free apo-like ADP pre-release conformation in kinesin-1 that is unaffected by its autoinhibitory tail

Fig. 6

a–d Views of the neck linker and coiled-coil of the MT-associated head of Kif5bMoNeIAK bound to a, b AMPPNP or c, d ADP in (a, c) one- or (b, d) two-headed states, with corresponding density in semi-transparent gray. In (c) and (d), the position where density for a docked neck linker could be expected (but is absent here) is indicated in semi-transparent cyan. All cryo-EM densities shown in (a–c) were filtered using DeepEMhancer62. In (d), the displayed density for the 1st head was filtered using DeepEMhancer62, while the density for the 2nd head displayed density was low-pass filtered to 6 Å resolution for resolution-appropriate visualization.

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