Fig. 4: Stepwise synthesis of the glycans. | Nature Communications

Fig. 4: Stepwise synthesis of the glycans.

From: Poly-β-D-(1,6)-N-acetyl-glucosamine (PNAG) glycan vaccines with broad spectrum neutralizing activities

Fig. 4

Reagents and conditions: a NIS/TfOH, CH2Cl2, −30 to −20 °C, 2 h 13: (n = 1) 84%, 15: (n = 3) 57%, 17: (n = 5) 49%, 19: (n = 7) 56%, 21: (n = 9) 45%, 23: (n = 11) 43%, 25: (n = 13) 48%, 27: (n = 15) 59%; and b AcCl, CH2Cl2/MeOH, RT, 1–2 d 14: (n = 3) 82%, 16: (n = 5) 88%, 18: (n = 7) 82%, 20: (n = 9) 87%, 22: (n = 11) 88%, 24: (n = 13) 88%, 26: (n = 15) 88%.

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