Fig. 6: Automated detection of empirical microbial responses using Kinbiont.

A Representative example illustrating the fitting procedure and parameter inference from an optical density (OD) time series of the methionine auxotroph strain at 10 μM methionine. All growth curves and optimal fits are provided in Supplementary Fig. 8. The exponential growth rate and maximum biomass concentration were extracted from the first and second segments, respectively. B Inferred exponential growth rates at varying methionine concentrations (green dots), plotted together with a subset of candidate equations from the symbolic regression hall-of-fame (Supplementary Table 2). The solid black line indicates the Monod equation. C Inferred maximum biomass concentrations at varying methionine concentrations (red dots), shown together with selected candidate equations from the symbolic regression hall-of-fame (Supplementary Table 3). The black line represents the linear substrate-yield relationship. D Inferred exponential growth rates at varying chloramphenicol concentrations (green dots), shown alongside selected candidate equations describing growth rate inhibition from symbolic regression (Supplementary Table 6). All growth curves and optimal fits are provided in Supplementary Fig. 9.