Fig. 3: Damaging genotypes in various gene categories/pathways are predictive of mortality for the most complex surgical procedures.
From: Genome sequencing is critical for forecasting outcomes following congenital cardiac surgery
Relative risk ratios for adverse post-operative outcomes and surgical complexity compare probands with and without damaging genotypes in various gene pathways or categories. Gene lists are described in Supplementary Data 3 and have been previously published5,8,9. There is overlap between gene lists, with some genes represented in more than one gene pathway/category (Supplementary Fig. 4). Each estimate shows the point estimate of the network propagated relative risk. Empirical ninety-five percent confidence intervals (CI 5, 95) were generated by resampling the data matrix with replacement and re-estimating the network propagated risk 1,000 times. Because the resampling distribution estimates may be constrained by the Bayesian network structure, error bars may not be symmetric with respect to the median point estimate. Target and conditional counts are listed in Supplementary Data 4.
