Fig. 6: Evaluation of TIVelo’s performance for single-cell multi-omics data compared with MultiVelo.
From: TIVelo: RNA velocity estimation leveraging cluster-level trajectory inference
a Comparative velocity stream plots of the HSPCs dataset generated by TIVelo, MultiVelo, and scVelo (dynamical mode). b The cluster graph after graph pruning and main path selection. The end cluster, Platelet, is selected as the origin node. The mean orientation score along the main path is −7.773. c Top: The depiction of three distinct lineages in the HSPCs dataset. Bottom: The u-s scatter plots and fitted velocity from TIVelo of three genes AZU1, KEL, and VWF. For each gene, u and s are expressed more differentially across cells in its above lineage than cells in other lineages. For each gene, cells not in its corresponding lineage are shown in the panel at the bottom right. The velocity vectors of three genes from TIVelo accurately reflect the developmental trajectory in their corresponding lineage. d A comparison of the cross-boundary direction correctness (CBDir) (UMAP space) score across four datasets. e A comparison of the cross-boundary direction correctness (CBDir) (Gene space) score across four datasets.
