Fig. 7: Cartoon summarising site one and site two tracer binding kinetics. | Nature Communications

Fig. 7: Cartoon summarising site one and site two tracer binding kinetics.

From: Multicolored sequential resonance energy transfer for detection of simultaneous ligand binding at G protein-coupled receptors

Fig. 7

Top shows fast binding of green site two tracer leads to a conformational change in the receptor. This likely close off access to the site one red tracer leading to both slow association and dissociation. Bottom shows fast association of the red site one tracer does not result in any change to the binding site for the green tracer, maintaining both fast association and dissociation.

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