Fig. 1: Strategies for RNA circularization. | Nature Communications

Fig. 1: Strategies for RNA circularization.

From: Chemical circularization of in vitro transcribed RNA for exploring circular mRNA design

Fig. 1

A Overview of existing circularization approaches. B Chemical circularization developed in this work. The 5′ modified linear RNA precursor is obtained from a 5′ initiator (EDA-AG, EP5AG or EP5Cap) during an in vitro transcription (IVT) reaction and is subsequently circularized by PORA reaction. The produced circRNA contains a single chemically modified linkage.

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