Fig. 9: In vivo translatability of chemically circularized RNA for human erythropoietin (hEPO). | Nature Communications

Fig. 9: In vivo translatability of chemically circularized RNA for human erythropoietin (hEPO).

From: Chemical circularization of in vitro transcribed RNA for exploring circular mRNA design

Fig. 9

A C57BL/6 female mice were intravenously inoculated with 1 µg of SM-102 -based LNP-formulated RNA. Blood was collected at the indicated time points to measure hEPO concentration with ELISA. Experimental setup. Created in BioRender. Chmieliński, S. (2025) https://BioRender.com/txhelkn. B hEPO concentration in serum over time, means ± SD, n = 5. Green stars: P < 0.01 for circ(EP5Cap)RNA18 vs each of the linear RNA group; teal stars: P < 0.01 for circ(EP5Cap)RNA19 vs each of the linear RNA group; ns—not significant (circ(EP5Cap)RNA18 vs circ(EP5Cap)RNA19), 2 way ANOVA with Tukey’s multiple comparisons test. Source data are provided as a Source Data file.

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