Fig. 1: Strategies for cocrystal transformations.

a Previously reported cocrystal-to-cocrystal transformations. b Molecular switching of indolino[2,1-b]oxazolidine (box) derivatives enables conversion from the open form to the closed form upon treatment with the base. c Molecular design of AIO. d Schematic illustration and molecular stacking mode of the cocrystal-to-polycrystal transformation driven by NEt3.