Table 1 Baseline characteristics of the 6 individual cohorts (and their study fractions) and their meta-cohort
From: Activated GDF11/8 subforms predict cardiovascular events and mortality in humans
Covariate | Measure | HUNT3 secondary | ARIC secondary | ARIC primary elderly | BASEL VIII secondary | BASEL VIII primary | EXSCEL Placebo baseline | Meta-cohort with 4-year outcomes |
|---|---|---|---|---|---|---|---|---|
Population | Purpose/duration | Studies or study fractions with 4 year outcomes included in meta-cohort | All 4 year studies merged dataset | |||||
Study fraction and Morbidity | 20% of total secondary population | 80% of total visit 5 secondary population | 100% of visit 5 primary population aged >65 | 100% secondary w/CAD symptoms | 100% primary w/CAD symptoms | 100% of placebo; type 2 diabetes | Multi morbidity | |
Sample size | 139 | 784 | 4078 | 2410 | 1675 | 2523 | 11,609 | |
Composite CV Event | Event (%) | 37 (26.6%) Death=14 CHF = 10 MI = 10 Stroke = 3 | 390 (49.7%) Death=72 CHF = 207 MI = 80, Stroke = 31 | 817 (20.0%) Death=350 CHF = 253 MI = 109 Stroke=105 | 627 (26.0%) Death=236 CHF = 77, MI = 218 Stroke = 96 | 181 (10.8%) Death=124 CHF = 18 MI = 11 Stroke = 28 | 488 (19.3%) Death=176 CHF = 57, MI = 173 Stroke = 82 | 2540 (21.9%) Death=972 CHF = 622 MI = 601 Stroke = 345 |
No event (%) | 102 (73.4%) | 394 (50.3%) | 3261 (80.0%) | 1783 (74.0%) | 1494 (89.2%) | 2035 (80.7%) | 9069 (78.1%) | |
Follow-up time (days) | Mean events (SD) Range | 638 (432) 4−1675 | 910 (616) 7 – 2232 | 1136 (580) 4-2375 | 776 (647) 1 - 2958 | 863 (679) 7 - 2822 | 725 (477) 1-1950 | 907 (614) 1 - 2958 |
Mean no events (SD) Range | 1721 (175) 1407 - 2035 | 2019 (257) 238 – 2389 | 2042 (235) 134-2404 | 1421 (669) 361 - 3024 | 1392 (681) 267 - 3054 | 1423 (346) 1-2112 | 1674 (558) 1 - 3054 | |
Age (years) | Mean (SD) Range | 69.5 (10.8) 44−92 | 77.2 (5.3) 67−90 | 75.3 (5.1) 66-90 | 68.1 (10.6) 34 - 93 | 65.9 (11.8) 26 - 95 | 62.8 (9.4) 29 – 88 | 69.8 (10.1) 26 - 95 |
Sex | Male (%) | 108 (77.7%) | 498 (63.5%) | 1581 (38.8%) | 1891 (78.5%) | 855 (51.0%) | 1520 (60.2%) | 6453 (55.6%) |
Female (%) | 31 (22.3%) | 286 (36.5%) | 2497 (61.2%) | 519 (21.5%) | 820 (49.0%) | 1003 (39.8%) | 5156 (44.4%) | |
Race | White (%) | n/a | 652 (83.2%) | 3322 (81.5%) | n/a | n/a | 2032 (80.5%) | 10,230 (88.2%) |
Black (%) | n/a | 132 (16.8%) | 756 (18.5%) | n/a | n/a | 44 (1.7%) | 932 (8%) | |
Asian (%) | n/a | 0 | 0 | n/a | n/a | 176 (7.0%) | 176 (1.5%) | |
Latine (%) | n/a | 0 | 0 | n/a | n/a | 260 (10.3%) | 260 (2.2%) | |
Other (%) | n/a | 0 | 0 | n/a | n/a | 11 (0.4%) | 11 (0.10%) | |
