Fig. 4: Mechanistic studies.
From: Bioinspired transfer methylation enabled by a photoactive reagent
See the Supplementary Information for detailed conditions. A Deuteration experiment. The deuterium degree is determined by NMR. TFA, trifluoroacetic acid. DCM, dichloromethane. LED, light-emitting diode. B Kinetic isotope effect (KIE) measurement. C Trapping of α-aminomethyl radical. DMPO, 5,5-dimethyl-1-pyrroline N-oxide. EPR, electron paramagnetic resonance. ESI-HRMS, electrospray ionisation high-resolution mass spectroscopy. dTMP, deoxythymidine monophosphate. dUMP, deoxyuridine monophosphate. Expt., experiment. Calc., calculation.
