Fig. 3: Differential choroid plexus gene expression as a function of age.
a Gene expression density between the different age states. Gene density (y-axis) versus gene expression in log10(Median Ratio Normalization (MRN) (x-axis). Insert highlights gene expression between log10 (MRN) of −0.5 and 2. b PCA plot of the different age groups with the three major clusters of age groups encircled. c Genes shared between the age groups (excluding genes expressed lower than 10 TMM). d GO enrichment analysis of the molecular functions of the differentially expressed genes. e Expression level of the differentially expressed genes within each category of molecular functions across all age groups. The expression levels are the z-score of the mean (circles) with the 95% confidence interval indicated as shaded area. n = 3. 1 M; turquoise, 3 M; green, 6 M; orange, 12 M; red, 18 M; purple, 24 M; grey. Statistical significance was tested with one-way ANOVA followed by Tukey’s multiple comparisons post hoc test. Asterisks denote statistical significance between the age groups (*; P < 0.05, **; P < 0.01, ***; P < 0.001). Non-significance is not illustrated for clarity. Source data are provided as a Source Data file and exact P-values in Supplementary Data 2.
