Fig. 3: Surface-based transcriptomic decoding of the serotonergic 1A receptor (5-HT_1AR).

a Spatial correlations between the average receptor density (B_max) of the 5-HT_1AR based on the high-resolution in vivo Positron Emission Tomography (PET) atlas of the human serotonergic system provided by ref. ¹⁵ (upper panel) and the predicted mRNA expression profile of the HTR1A gene (lower panel). b False positive rate (FPR) of the α-null (blue), Linear Mixed Effects (LME, red), and General Least Squares (GLS, yellow) decoding techniques across different adjusted p-value thresholds (p_adj). For LME- and GLS-decoding, p-values were adjusted for multiple comparisons using False Discovery Rate (FDR) adjustments. For α-null decoding, adjusted permutation p-values (p_perm,adj) were used. c Spearman rank correlations between the gene weights across approaches. Gene weights were determined by the slope of the regression line (i.e., beta) for the LME- and GLS-decoding approach, and by the spatial Pearson correlation between receptor density and gene expression maps for the α-null decoding approach. ^** p-value < 0.001 (two-tailed). d Intersection of gene sets with a significant transcriptomic association with the target pattern across various decoding methods. Gene set intersections and total set sizes are shown at an adjusted p-value threshold of 0.05 (left panel), 0.01 (middle panel), and 0.001 (right panel).