Fig. 1: Functional and structural profiles of ρ1 with antagonist and agonist drugs.
From: Cryo-EM structures of ρ1 GABAA receptors with antagonist and agonist drugs
a–c Sample traces from two-electrode voltage-clamp electrophysiology recordings of ρ1-EM expressed in Xenopus oocytes exposed to THIP, CGP36742 or GABOB. d Cryo-EM maps of human ρ1-EM in complex with THIP (left), CGP36742 (middle) or GABOB (right), viewed from the extracellular side. Maps are colored by assigned functional states as similar to resting (green), partially locked (purple), or desensitized (blue). Low-pass filtered maps are shown in transparency to reveal lower-resolution features including the nanodisc and M3-helix intracellular-domain extension (M3 ICD). e Cryo-EM maps as in (d), viewed from the membrane plane. Insets show the drugs with corresponding densities.
