Fig. 5: Partially-locked and desensitized states captured with GABOB.
From: Cryo-EM structures of ρ1 GABAA receptors with antagonist and agonist drugs
a Superimposed structures of the GABOB-bound partially-locked state (purple) with a previously reported resting state (green, PDB 8OQ6). Structures are aligned on the TMD; for clarity, all but one of the subunits are semi-transparent. Labeled distance in the zoomed figure is between S264 Cα positions in the two structures. The S264 side chain is shown as sticks, including polar hydrogens, with oxygen and hydrogen colored red and gray respectively. b Superimposed structures of GABOB-bound partially-locked state (purple) and desensitization state (blue). The structures are aligned with the TMD domain, and for clarity all but one of the subunits are transparent.
