Fig. 5: Proposed mechanism of LYCHOS.
From: Structural insights into cholesterol sensing by the LYCHOS-mTORC1 pathway
Up: Under low cholesterol, LYCHOS is in an expanded state in the absence of cholesterol. GATOR1 promotes GTP hydrolysis of RagA/B, maintaining mTORC1 in the cytosol and inactive. Down: When cholesterol is sufficient, binding of cholesterol induces the contraction of the GLD and the descending of TM15, makes the LED suitable for interaction with GATOR1, thus facilitating the GTP-loaded state of RagA/B that recruits mTORC1 to the lysosome and activate it.
