Fig. 3: Alterations in immune-related cytokine and cytotoxic molecule expression profiles in early pregnancy serum of EPL patients.
From: Enrichment of decidual CD11c + CD8 + T cells with altered immune function in early pregnancy loss
A Violin plots displaying the distribution of 12 serum biomarkers in the HC group (n = 32) and the EPL group (n = 32). The P value was obtained by the Mann-Whitney U test (A), and data are presented as median with interquartile range. B ROC curves showing the performance of the 12 serum biomarkers in predicting EPL risk. C ROC curves of a combined prediction model using the top four differentially expressed serum biomarkers (IL-17A, IFN-γ, perforin, and granulysin). The combined model achieved an AUC of 0.95 (95% CI: 0.89-1.00, P < 0.0001), with a sensitivity of 81.25% and specificity of 96.88%. P value was calculated using DeLong’s two-sided test for ROC curve comparisons. The combination model was derived using logistic regression. EPL early pregnancy loss, HC healthy control, ROC receiver operating characteristic, AUC area under the curve. Source data are provided as a Source Data file.
