Fig. 1: Sociability and social aggression are impaired in Shank3B+/- mice. | Nature Communications

Fig. 1: Sociability and social aggression are impaired in Shank3B+/- mice.

From: Impaired vasopressin neuromodulation of the lateral septum leads to social behavior deficits in Shank3B+/- male mice

Fig. 1

a Schematic of the sociability test (Created in BioRender. Leroy, F. (2025) https://biorender.com/8v51vnv). b Heatmap of the accumulated time around the empty or social cup. c Time spent interacting with the empty or social cup (9/8 mice. Paired t test, WT: p = 0.03; Paired t test, Shank3B+/-: p = 0.01). d Discrimination indexes for social preference (9/8 mice. Unpaired t test: p = 0.003). e Schematic of resident-intruder test (Created in BioRender. Leroy, F. (2025) https://BioRender.com/in0mntf). f Example frames showing social exploration, dominance, and aggression. g Raster plots showing social exploration, dominance, and aggression. h Proportions of mice exhibiting only social exploration, social dominance without aggression or aggression (at least one biting attack) (11/13 mice. Chi-squared test: χ²(1) = 4.06, p = 0.04). i Social interaction duration (11/13 mice. Unpaired t test: p = 0.02). j Social dominance duration (11/13 mice. Unpaired t test: p = 0.2). k Latencies to attack (11/9 mice. Unpaired t test: p = 0.02). l Attack durations (11/13 mice. Unpaired ttest: p = 0.005). For the entire figure, bar graphs represent mean ± s.e.m. Each point is one mouse. * p < 0.05, ** p < 0.01, *** p < 0.001. Source data are provided as a Source Data file.

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