Fig. 7: Application of Ufd1s-coding plasmid or circRNA alleviates NASH progression. | Nature Communications

Fig. 7: Application of Ufd1s-coding plasmid or circRNA alleviates NASH progression.

From: A UFD1 variant encoding a microprotein modulates UFD1f and IPMK ubiquitination to play pivotal roles in anti-stress responses

Fig. 7

a Two strategies, plasmid and circRNA, to express Ufd1s protein in NASH mice. b Representative Ufd1s IHC images and quantification in liver sections of NASH mice (N = 6 mice) with pLIVE, pLIVE-Ufd1s, circUfd1sATG-ATT, and circUfd1s injection. pLIVE plasmid vector control, circUfd1sATG-ATT circUfd1s with start codon mutation from ATG to ATT. Scale bar, 50 μm. Serum triglycerides, total cholesterol (c), AST and ALT (d) levels of NASH mice (N = 6 mice). e Representative images and quantification of H&E, Oil Red O, Masson staining, Ipmk, and LC3 IHC of liver sections (N = 6 mice). Scale bar, 50 μm. Data from 6 mice are shown as mean ± SEM. P values were calculated by two-tailed Student′s t-test. Source data are provided as a Source Data file.

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