Fig. 6: Sub-clustering analysis on Monocytes. | Nature Communications

Fig. 6: Sub-clustering analysis on Monocytes.

From: Biomarkers of pediatric Epstein-Barr virus-associated hemophagocytic lymphohistiocytosis through single-cell transcriptomics

Fig. 6

a UMAP visualization of 5228 single cells from HV (n = 3), 7298 single cells from IM (n = 9), and 12,387 single cells from HLH (n = 17). The cells were divided into 10 clusters and color-coded accordingly. b, c Heatmap representing the average expression values of the highly expressed 10 genes (b) and functional genes (c) in each monocytes cluster. d Box plot depicting the percentage of each cell cluster in HV (n = 3), IM (n = 9), and HLH (n = 17) group, with the median indicated by a horizontal line. Two-sided Wilcoxon tests were performed between groups and P-values were adjusted using the BH correction. e Enriched GO terms of differentially expressed genes between Mono_C06_HLA-DQA1 cluster and the rest monocytes. The enrichment results were produced by clusterProfiler and BH-corrected.

Back to article page