Fig. 7: Immunological characterization of Monocytes clusters. | Nature Communications

Fig. 7: Immunological characterization of Monocytes clusters.

From: Biomarkers of pediatric Epstein-Barr virus-associated hemophagocytic lymphohistiocytosis through single-cell transcriptomics

Fig. 7

Enriched GO terms for upregulated genes in HLH patients compared to HV (a) and IM (b). c, d The expression levels of specific genes in all samples and their enrichment in the GO and KEGG pathways. The enrichment results were produced by Metascape and BH-corrected. Compared to the HV group and IM group, these genes were upregulated (c) or downregulated (d) in the HLH group. In contrast, expression levels between the HV and IM groups either showed no significant differences or exhibited a reverse trend. e Quantification of phosphorylated p65 levels (normalized MFI values) in monocytes from pediatric IM (n = 4) and HLH (n = 5) biologically independent samples. Two-sided Independent-samples t-test was applied. f, g The box plot shows the scoring of the inflammatory response set for each cell cluster among the three groups (HLH, HV, and IM). Comparisons were made using the two-sided Wilcoxon tests and P-values were adjusted using the BH correction.

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