Fig. 1: Reaction design for asymmetric migratory cross-electrophile coupling by radical π-system-independent 1,2-N-shift. | Nature Communications

Fig. 1: Reaction design for asymmetric migratory cross-electrophile coupling by radical π-system-independent 1,2-N-shift.

From: Asymmetric synthesis of β-amino acid derivatives by stereocontrolled C(sp3)-C(sp2) cross-electrophile coupling via radical 1,2-nitrogen migration

Fig. 1

a Typical migratory cross-coupling enabled by “NiH-chain walking” (previous studies). b Typical 1,n-Imino radical shift (Frey-1990, Han-2021). c Our design: Migratory cross-coupling with Ni/CPA cooperative catalysis. d Previous studies to access optimally pure bioactive β-amino acid motifs (For example). e Enantioselective migratory cross-electrophile coupling via 1,2-N-shit (This work).

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