Fig. 2: Scope of (hetero)aryl bromides and N-benzyl amino acid esters in Ni-catalyzed migratory couplinga. | Nature Communications

Fig. 2: Scope of (hetero)aryl bromides and N-benzyl amino acid esters in Ni-catalyzed migratory couplinga.

From: Asymmetric synthesis of β-amino acid derivatives by stereocontrolled C(sp3)-C(sp2) cross-electrophile coupling via radical 1,2-nitrogen migration

Fig. 2

aReaction conditions in “Method A”: alkyl bromide 1 (0.2 mmol), (hetero)aryl bromide 2 (2 equiv), NiBr2•dme (10 mol%), L1 (12 mol%), B2neo2 (2 equiv), H2O (2 equiv) K2CO3 (2 equiv) and CH3CN/EtOH (v: v = 1.8: 0.2, 0.1 M) at 50 °C under argon atmosphere for 30 h; isolated yields. b By-products arising from intramolecular C-H cyclization. c Diastereoselective ratio (dr) was determined by 1H NMR and/or 19 F NMR analysis.

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