Fig. 4: Mogat1 inhibition suppresses tumor growth in vivo.
From: Mogat1 drives metabolic adaptations to evade immune surveillance
a–c Growth curves of MMTV-PyMT tumors in immunocompetent FVB mice following inoculation with cells transduced with control shRNA (shCTRL, black), shMogat1_1 (blue), or shMogat1_2 (red). b Quantification of tumor volume and c weight at day 36 in the MMTV-PyMT model. (n = 8 mice in shCTRL and shMogat1_1 group, n = 7 mice in shMogat1_2 group). d–f Growth curves of 4T1 tumors in immunocompetent Balb/c mice following inoculation with cells transduced with shCTRL (black), shMogat1_1 (blue), or shMogat1_2 (red). e Quantification of tumor volume and f weight at day 25 in the 4T1 model. (n = 8 mice in shCTRL and shMogat1_1 group, n = 7 mice in shMogat1_2 group). g–i Growth curves of B16/F10 tumors in immunocompetent C57BL/6 mice following inoculation with cells transduced with shCTRL (black), shMogat1_1 (blue), or shMogat1_2 (red). h Quantification of tumor volume and i weight at day 17 in the B16/F10 model. (n = 6 mice per group). j, k Oil Red O staining of neutral lipids in tumor tissues from MMTV-PyMT mice with control shRNA (shCTRL) or two independent Mogat1 shRNAs (shMogat1_1, shMogat1_2). Scale bar: 100 μm. (n = 6 mice per group). Data are representative of two independent experiments from 6 to 8 mice per group per experiment. Data are presented as mean ± SD (b, c, e, f, h, i, k) and mean ± SEM (a, d, g). Statistical analysis was conducted by two-way ANOVA followed by Tukey’s multiple comparison test (a, d, g). Statistical significance was calculated using one-way ANOVA (b, c, e, f, h, i, k). ns, not significant. Source data are provided as a Source Data file.
