Fig. 3: Co-recognition of K20-HTS-Tail and K11-HTS-Tail by KAP-1ΔN for assembling the heterotrimeric complex. | Nature Communications

Fig. 3: Co-recognition of K20-HTS-Tail and K11-HTS-Tail by KAP-1ΔN for assembling the heterotrimeric complex.

From: A mutual co-recognition mechanism ensures the proper assembly of heterotrimeric kinesin-2 for intraflagellar transport

Fig. 3

a A ribbon diagram of the crystal structure of the K20-HTS-Tail/K11-HTS-Tail heterodimer showing an intertwined HTS heterodimer and a bundle-like structure formed by the two motor tails (indicated by dashed boxes). b, c A close-up view of the intertwined HTS heterodimer (b) and a bundle-like structure (c) of the K20-HTS-Tail/K11-HTS-Tail heterodimer. d Surface representation of the KAP-1ΔN structure showing the central concave groove in the middle and a C-terminal CTH-hook. e Co-recognition of K20-HTS-Tail and K11-HTS-Tail by KAP-1ΔN. The central groove of KAP-1ΔN co-recognizes the motor tails of KLP-20 and KLP-11, acting as a clamp to grasp the bundle-like structure. Meanwhile, the CTH-hook of KAP-1ΔN inserts into a pocket at the top of the HTS heterodimer, enabling mutual co-recognition to complete the assembly of the heterotrimeric complex.

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