Fig. 2: Multiple Sclerosis (MS) discriminability across task performance metrics and task selection for the C-MS battery. | Nature Communications

Fig. 2: Multiple Sclerosis (MS) discriminability across task performance metrics and task selection for the C-MS battery.

From: Large-scale online assessment uncovers a distinct Multiple Sclerosis subtype with selective cognitive impairment

Fig. 2

A MS discriminability in terms of accuracy, cost in accuracy (top), response time, and cost in response time (bottom) across tasks for Stage 1 participants (N = 3048; task-specific Ns in Table S1). MS discriminability is defined as the median deviation from expected (DfE) score across participants with 95% confidence intervals for each performance metric. Tasks selected for inclusion in the C-MS battery are reported in green. The primary performance metric for each task is indicated by a blue square. The orange line represents the control median. B Heatmap of factor loadings across primary performance metrics. Tasks selected for each factor are indicated by green squares. C Heatmap of correlations between task performance metrics (top: accuracy and cost in accuracy; bottom: response time and cost in response time) and patient-reported outcomes (PROs) including MSIS-29 motor, MSWS-12, HADS-A, HADS-D, FSS, EQ5D and webEDSS. Only statistically significant (p ≤ 0.05) correlations are shown. D Grid indicating with a green check mark whether a task was selected for the C-MS battery. Source data are provided as a Source Data file.

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