Fig. 3: Replication of Multiple Sclerosis (MS) discriminability across stages and comparative validity with standard neuropsychological assessment.

A Scatter plots showing MS discriminability in terms of accuracy (left) and response time (right) across tasks for Stage 1 (x-axis, N = 3048) and the independent sample from Stage 2 (y-axis, N = 1425). MS discriminability is defined as the median deviation from expected (DfE) score across participants for each performance metric and is evaluated separately for each stage. Two-tailed Pearson correlation coefficients and corresponding p-values between values at Stage 1 and Stage 2 for accuracy and response time are reported on the plots. B Scatter plots showing global composites of cognitive performance (left) and hand motor function (right) across Stage 3 participants (N = 31), as measured by the standard neuropsychological assessment (x-axis) and the C-MS battery (y-axis). Global cognitive composites were derived by averaging standardised performance scores across tasks within each battery. Nine-Hole Peg Test scores correspond to the less impaired hand. Two-tailed Pearson correlation coefficients and corresponding p-values between global cognitive composites and hand motor function scores from the standard and online assessments are reported on the plots. Source data are provided as a Source Data file.