Fig. 2: Synthesis and charge neutralization of ɑ-guanidinium esters (AGE).
From: Discrete Immolative Guanidinium Transporters deliver mRNA to specific organs and red blood cells
a Synthesis of model substrate 4 to investigate AGE degradation. b Formation of 5 monitored by 1H NMR. c Regioselectivity of cyclization characterized by 1H-13C HMBC. Ha-Cd coupling was detected (black arrow), which can only occur when the N1 isomer is formed.
