Fig. 2: Principal component analysis generates 3 phenotypic components of cardiac remodeling. | Nature Communications

Fig. 2: Principal component analysis generates 3 phenotypic components of cardiac remodeling.

From: Integrated multiomics of pressure overload in the human heart prioritizes targets relevant to heart failure

Fig. 2

We used principal component analysis (PCA) on 12 echocardiographic measures of cardiac structure and function in the discovery cohort derivation sample (N = 519) and identified 3 composite axes of remodeling that accounted for 65% of the variance. A Loadings for each of the 3 principal components. B Heatmap demonstrating individual level data on the 12 echocardiographic measures and participants’ corresponding principal component value. Source data are provided as a Source Data file. PC principal component, LV left ventricular, RWT relative wall thickness, SVI stroke volume index, AV aortic valve, LVEF left ventricular ejection fraction, LV DTI LV tissue Doppler S lateral annulus, LVESDI left ventricular end-systolic diameter index, LVEDDI left ventricular end-diastolic diameter index, LVESVI left ventricular end-systolic volume index, LVEDVI left ventricular end-diastolic volume index, LVMi left ventricular mass index, LA Vol left atrial volume.

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