Table 1 Baseline characteristics of AS Biomarker Study (discovery cohort)

From: Integrated multiomics of pressure overload in the human heart prioritizes targets relevant to heart failure

Characteristic

Overall N = 825

Derivation N = 519

Validation N = 306

P value

Age (years)

83 (77, 88); 0%

84 (78, 88); 0%

82 (76, 87); 0%

0.010

Women

359 (44%); 0.1%

233 (45%); 0.2%

126 (41%); 0%

0.3

Race

   

0.043

Black

19 (2.3%); 0%

17 (3.3%); 0%

2 (0.7%); 0%

 

Asian

8 (1.0%); 0%

6 (1.2%); 0%

2 (0.7%); 0%

 

Other

2 (0.2%); 0%

1 (0.2%); 0%

1 (0.3%); 0%

 

White

796 (96%); 0%

495 (95%); 0%

301 (98%); 0%

 

Body mass index (kg/m2)

27.6 (24.3, 31.9); 0%

27.3 (23.8, 31.4); 0%

28.0 (24.8, 33.2); 0%

0.010

Diabetes

320 (39%); 0.1%

184 (36%); 0.2%

136 (44%); 0%

0.011

Coronary artery disease

577 (70%); 0.1%

368 (71%); 0.2%

209 (68%); 0%

0.4

History of atrial fibrillation or flutter

330 (40%); 0.5%

200 (39%); 0.4%

130 (43%); 0.7%

0.2

LV ejection fraction (%)

61 (53, 66); 3.2%

61 (53, 66); 0%

60 (52, 66); 8.5%

0.3

LV mass index (g/m2)

107 (90, 126); 18%

108 (91, 126); 0%

105 (90, 127); 47%

0.8

LVH (ASE Grading)

   

0.9

Normal

346 (51%); 18%

266 (51%); 0%

80 (50%); 47%

 

Mild

118 (17%); 18%

87 (17%); 0%

31 (19%); 47%

 

Moderate

91 (13%); 18%

69 (13%); 0%

22 (14%); 47%

 

Severe

125 (18%); 18%

97 (19%); 0%

28 (17%); 47%

 

LV end-systolic internal diameter index (mm/m2)

15.5 (13.2, 18.7); 18%

15.5 (13.4, 18.6); 0%

15.1 (12.8, 18.7); 48%

0.4

LV end-diastolic internal diameter index (mm/m2)

23.3 (20.9, 26.1); 18%

23.5 (21.2, 26.2); 0%

22.4 (20.2, 25.5); 47%

0.037

Relative wall thickness

0.54 (0.45, 0.64); 18%

0.54 (0.45, 0.64); 0%

0.55 (0.45, 0.65); 47%

0.4

LV end-systolic volume index (ml/m2)

17 (12, 25); 22%

17 (12, 25); 0%

18 (12, 27); 59%

0.5

LV end-diastolic volume index (ml/m2)

44 (35, 55); 22%

44 (35, 54); 0%

45 (35, 55); 59%

0.8

LV tissue Doppler S lateral annulus (m/s)

0.065 (0.053, 0.078); 22%

0.064 (0.053, 0.078); 0%

0.065 (0.054, 0.076); 59%

0.5

Stroke volume index (ml/m2)

37 (29, 44); 16%

37 (30, 45); 0%

35 (28, 42); 42%

0.044

Average transmitral E/e’

18 (14, 24); 26%

18 (14, 24); 0%

17 (12, 24); 69%

0.4

Left atrial volume index (ml/m2)

36 (27, 48); 17%

35 (27, 47); 0%

37 (30, 48); 46%

0.2

Aortic valve mean gradient (mmHg)

39 (31, 49); 2.8%

39 (32, 50); 0%

38 (30, 49); 7.5%

0.3

High-sensitivity cardiac troponin (ng/ml)

25 (16, 41); 2.9%

25 (16, 41); 3.5%

25 (16, 41); 2.0%

0.8

NT-proBNP (pg/ml)

1,277 (602, 3,281); 2.9%

1,303 (622, 3,374); 3.5%

1,238 (557, 3,049); 2.0%

0.5

eGFR (ml/min/1.73m2)

58 (45, 75); 0.7%

58 (45, 75); 0.6%

58 (44, 75); 1.0%

0.5

  1. Continuous variables are reported as median (25th, 75th percentile); % missing, categorical variables are reported as n (%); % missing. P-values for continuous variables are from Wilcoxon rank-sum tests, p-values for categorial variables are from Chi square tests or Fisher’s exact test. eGFR estimated glomerular filtration rate, LV left ventricular, NT-proBNP N-terminal pro hormone B-type natriuretic peptide.
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