Fig. 7: Multi-omic analysis of complex POE on PSEs.
From: Mechanism of parent-of-origin effects revealed by multi-omic data in euro-chinese hybrid pigs
a The number of PSEs with PSHM in the opposite direction from PSMR and PSHM in the same direction from PSMR in BF and LD. b The well-known POE model of the H19-IGF2 locus, along with the epigenetic landscape of parental allele-specific modifications at this locus. c Schematic diagram of the regulation of H19 and IGF2 between the paternal phase and the maternal phase. d The 3D chromatin structure and epigenetic landscape of SGCE-PEG10 between the paternal phase and the maternal phase. The blue column highlighted ICR of SGCE-PEG10. The tracks from top to bottom represent ICR-related elements, including PSTAD boundaries, phase-specific compartments, PSLoops, PSCTCF, PSMR, differential DNA methylation levels, differential expression levels, and PSHMs between the paternal and maternal phases. e Chromatin interactions in 500 kb upstream and downstream of the PSMR between the paternal and maternal phases, showing a significant difference in the frequency of chromatin interactions in the 100–250 kb upstream region. Box plots illustrate the median (depicted by the center line) along with the 25th and 75th percentiles (represented by the box edges), while the whiskers show the 1.5x interquartile range above and below the box. The paired two-sided t-test was employed to calculate the differences of chromatin interactions between phases. f Schematic diagram of the regulation of SGCE- PEG10 between the paternal phase and the maternal phase.
