Fig. 2: CHEK1 holds potential to be target for mitochondria-targeted therapy.
From: Mitochondrial inflexibility ignites tumor immunogenicity in postoperative glioblastoma
a t-SNE plot integrating single-cell transcriptomic data from 11,829 cells obtained from 6 GBM samples. Eight distinct cell clusters have been identified and annotated based on their transcriptional profiles. b Dot plot displaying the expression of signature genes specific to each of the eight identified cell clusters. The color of the dots represents the relative expression level of the genes, and the size of the dots indicates the proportion of cells expressing the gene within each cluster. c t-SNE plot highlighting the distribution of GBM cells according to their cell cycle state. d t-SNE plot visualizing the distribution of cells with varying levels of CHEK1 expression. e Bar chart presenting the proportions of cells expressing the CHEK1 gene within each of the eight cell clusters. f Gene Ontology (GO) terms significantly enriched among genes co-expressed with CHEK1. g Kyoto Encyclopedia of Genes and Genomes (KEGG) pathways significantly enriched in cells expressing the CHEK1.
