Fig. 6: Persistence of CD8+ TILs and PD-L1 overexpression on tumor cells are found in xenograft gliomas. | Nature Communications

Fig. 6: Persistence of CD8+ TILs and PD-L1 overexpression on tumor cells are found in xenograft gliomas.

From: Polyclonal expansion of functional tumor-reactive lymphocytes infiltrating glioblastoma for personalized cell therapy

Fig. 6

a, b Representative Hematoxylin&Eosin staining images showing the morphological characteristics of (a) tumors from control (n = 7) and (b) TIL-treated (n = 7) mice 60 days after tumor cell implantation (Scale bar, 500 and 400 μm); c, d anti-human CD3 staining performed on tumors revealed the presence of TILs in treated but not control mice (Scale bar, 300 and 100 μm, respectively); (d inset) TILs persisting within the tumor mass were positive for CD8 (Scale bar, 100 μm). e, f PD-L1 staining of tumors (e) from control and (f) TIL-treated mice 60 days after tumor cell implantation (Scale bar, 100 and 500–300 μm, respectively). g, h Anti-human GFAP staining showing (h) a barrier surrounding tumor masses in treated mice (Scale bar 300 and 200 μm).

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